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Clinical studies reveal a nuanced picture: the SUSTAIN-6 trial involving over 3,000 patients found that semaglutide users experienced modest reductions in systolic blood pressure over time, largely attributed to weight loss rather than the drug directly lowering pressure

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However, given the many well-known downsides of these medicationswhich range from hefty price tags to a high likelihood of non-adherence to an increased risk of lean muscle mass lossusing GLP-1s as a standalone solution to treat obesity and its comorbid conditions fails to truly drive value and move the needle on holistic health

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